"Today Christmas has become a commercial celebration, whose bright lights hide the mystery of God's humility, which in turn calls us to humility and simplicity," he said on Saturday in his homily to about 10,000 people in the basilica.
The pontiff urged the world’s billion-plus Roman Catholics to look beyond the holiday's "superficial glitter" to discover its true meaning.
"Let us ask the Lord to help us see through the superficial glitter of this season, and to discover behind it the child in the stable in Bethlehem, so as to find true joy and true light."
The 84-year-old pope, celebrating the seventh Christmas season of his pontificate, also urged that those marking the holiday in poverty, suffering or far from home not be forgotten.
"Let us strip away our fixation on what is material, on what can be measured and grasped. Let us allow ourselves to be made simple by the God who reveals himself to the simple of heart," he said as millions watched him on television throughout the world.
On Christmas Day, the pope will deliver his twice-yearly Urbi et Orbi (to the city and the world) message and blessing from the central loge of St Peter's Basilica.
At the start of a Christmas Eve service, he was wheeled up the central aisle of St Peter's Basilica standing on a mobile platform which he has been using since October.
He also issued a scathing rebuke against "oppressors" and warmongers around the world saying Christ would be victorious over them.
"God has appeared: as a child. It is in this guise that he pits himself against all violence and brings a message that is peace," he said.
It was the second time in as many days that Benedict has pointed to the need to rediscover faith to confront the problems facing the world today.
In his end-of-year meeting with Vatican officials on Thursday, Benedict said Europe's financial crisis was largely "based on the ethical crisis looming over the Old Continent".
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